Role of aspirin, beta-blocker, statins, and heparin therapy in septic patients under mechanical ventilation: a narrative review

Sepsis is the main cause of death among patients admitted to intensive care units. Management sepsis includes fluid resuscitation, vasopressors, intravenous antimicrobials, source control, mechanical ventilation, and others. New insights into potential benefits non-antimicrobial drugs in have evolved based on pathophysiology disease mechanism action some drugs, but findings are still controversial. In this study, we aimed evaluate effect beta-blockers, aspirin, statins, heparin as adjunctive treatments septic under ventilation with non-cardiovascular diseases their mortality. We searched PubMed relevant keywords (beta-blockers, or heparin, critically ill sepsis) for last 10 years personal collection articles, then assessed studies according prespecified inclusion exclusion criteria. Our results show that may promising feedback reducing However, new well-controlled, randomized, multicenter needed confirm that, multiple issues regarding usage need be addressed. On other hand, effectiveness statins was not strong studied, suggest further research these results.